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Table 2 Adverse events

From: A pilot dose finding study of pioglitazone in autistic children

Event

# Participants

Eye disorders

 Eye redness

1

Oral/gastrointestinal disorders

 Vomiting

3

 Abdominal pain

2

 Constipation

1

 Diarrhea

1

 Mouth sore/dry lips

2

 Tooth problem

6

General disorders

 Increased energy/behavioral activation

3

 Fatigue

1

 Increased sweating

1

Immune system disorders

 

 Neutropenia

3

Infections

 Fever

1

 Gastroenteritis

3

 Upper respiratory tract infection

11

Injury

 Skin bruise

1

 Skin burn

1

 Insect bite

2

Appetite

 Decreased appetite

2

 Increased appetite

1

Musculoskeletal

 Muscle pain/cramps

2

Nervous system disorder

 Concentration difficulty

1

 Headache

1

Psychiatric disorders

 Disinhibition/silliness

2

 Increased impulsivity

1

 Emotional lability

2

 Increased aggression/irritation/anger

5

 Insomnia (initial/mid-cycle)

6

 Negative thoughts

1

 Self-injurious behavior

2

Genitourinary

 Diurnal/nocturnal enuresis

3

 Increased urinary frequency

1

 Genital discomfort

1

Respiratory

 Cough

1

 Nasal congestion

2

 Sleep apnea

1

 Throat clearing

1

Skin

 Skin rash

2

 Skin scratching/picking

3

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Molecular Autism

ISSN: 2040-2392