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Fig. 2 | Molecular Autism

Fig. 2

From: Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome

Fig. 2

Behavioral testing of Ube3amLSL/Nestin-Cre mice show a full rescue of most AS-like behavioral phenotypes. a Schematic representation of Ube3a gene reactivation during mouse embryonic development around 2 weeks of gestation and time point of behavioral testing. b–e Accelerating rotarod test, nest building test, marble burying test, and forced swim test in WT and Ube3amLSL mice (WT, n = 28; Ube3amLSL/Cre−, n = 14; Ube3amLSL/Cre+, n = 12). A repeated measures ANOVA or univariate ANOVA was used for statistical comparison of genotypes. Asterisk indicate significant effects of genotype: *P < 0.05; **P < 0.01; ***P < 0.001

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Molecular Autism

ISSN: 2040-2392