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Table 1 Gene expression changes between control and TSC patient neurons

From: Pharmacological intervention to restore connectivity deficits of neuronal networks derived from ASD patient iPSC with a TSC2 mutation

Target gene

RNA abundance (mean ± SEM)

Change

Control neurons

TSC neurons

GABAergic cells

DLX1

0.016 ± 0.009

0.002 ± 0.0004

 

DLX2

0.03 ± 0.01

0.05 ± 0.01

 

LHX6

0.08 ± 0.02

0.11 ± 0.02

 

VGAT

0.03 ± 0.01

0.04 ± 0.01

 

Synaptic

PSD95

0.21 ± 0.05

0.12 ± 0.02

 

Synaptophysin

0.07 ± 0.01

0.11 ± 0.03

 

Homer1

0.37 ± 0.07

0.43 ± 0.05

 

GABA/glutamate signalling

GAD65

0.034 ± 0.02

0.17 ± 0.07*

↑

GAD67

0.13 ± 0.07

1.74 ± 0.61**

↑

GABAα1

0.33 ± 0.05

0.50 ± 0.02

 

GABAα2

0.31 ± 0.06

1.14 ± 0.07***

↑

GABAβ1

0.72 ± 0.09

1.59 ± 0.43*

↑

GABAγ1

0.062 ± 0.006

0.26 ± 0.03***

↑

Grin2a

0.27 ± 0.08

0.14 ± 0.007

 

Grin2b

1.35 ± 0.26

0.82 ± 0.06

 

Grin3A

0.13 ± 0.036

0.29 ± 0.05*

↑

GRIN1

0.07 ± 0.007

0.18 ± 0.04**

↑

GRIA1

1.03 ± 0.14

3.51 ± 1.04*

↑

Vglut1

0.06 ± 0.009

0.004 ± 0.002**

↓

Vglut2

0.1 ± 0.04

3.11 ± 0.85**

↑

  1. *p <  0.05; **p < 0.01; ***p < 0.001 (unpaired t test)
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Molecular Autism

ISSN: 2040-2392