Fig. 2

Intellectual, adaptive and motor functioning. a Frequency histograms of verbal, nonverbal, and fullscale developmental quotients (VDQ, NVDQ, DQ). b Frequency histograms of standard scores on domains of the Vineland-3: Adaptive Behavior Composite, Communication, Daily Living Skills, Socialization, and Motor (the Maladaptive Behavior domain is represented in Additional file 2: Fig. S1B). All plots show frequency (i.e., number of individuals) in each bin. Developmental delays of 25%, 50%, and 75% are indicated by dashed lines (a), while distribution of standard scores in typically developing individuals are shown as black lines (b), together with associated standard deviations (dashed lines). PTV, protein-truncating variant; missense, missense variant or in-frame deletion