Table 1 Study approach
From: Prospective and detailed behavioral phenotyping in DDX3X syndrome
Domain | Measure |
|---|---|
Intellectual and Adaptive Functioning | Stanford-Binet Intelligence Scales, Fifth Edition Differential Abilities Scales, Second Edition (DAS-II) Mullen Scales of Early Learning Vineland Adaptive Behavior Scales, Third Edition (Vineland-3) |
Motor Functioning | Autism Diagnostic Interview-Revised (ADI-R) subscales, ADI Regression supplement Clinical evaluation by a psychiatrist Vineland-3 Beery-Buktenica Developmental Test of Visual-Motor Integration, Sixth Edition (VMI-6) Developmental Coordination Disorder Questionnaire (DCDQ) |
Expressive and Receptive Language | ADI-R subscales Expressive Vocabulary Test, Second Edition Peabody Picture Vocabulary Test, Fourth Edition Vineland-3 MacArthur-Bates Communicative Development Inventory |
ASD Symptomatology | Clinical evaluation by a psychiatrist ADI-R Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) Social Responsiveness Scale, Second Edition (SRS-2) Repetitive Behavior Scale-Revised (RBS-R) |
Sensory Features | Sensory Assessment for Neurodevelopmental Disorders (SAND) Short Sensory Profile (SSP) |
Behavioral Comorbidities | Achenbach Child Behavior Checklist (CBCL) Aberrant Behavior Checklist Vineland-3 Clinical evaluation by a psychiatrist |
Medical Evaluation | Medical and psychiatric history/evaluation Neurological exam Dysmorphology exam Review of neuroimaging Pervasive Developmental Disorder Behavior Inventory |