Skip to main content
Fig. 3 | Molecular Autism

Fig. 3

From: Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K)

Fig. 3

eEF2K deletion enhances GABAergic transmission in Scn1a ± mice. A Representative sIPSC traces measured in hippocampal neurons of CA1 region of WT, Scn1a ± and Scn1a ± eEF2K−/− mice. B,C Quantification of peak amplitude (B) and instantaneous frequency (C) from sIPSC traces. All data are presented as mean ± SEM. Statistical analysis for peak amplitude **p < 0.001, %%p < 0.05 versus corresponding WT; $$p < 0.001 versus Scn1a ± ; One-way ANOVA, Bonferroni. Statistical analysis for instantaneous frequency **p < 0.001, %p < 0.01 versus corresponding WT; $$p < 0.05 versus Scn1a ± ; One-way ANOVA, Bonferroni

Back to article page

Molecular Autism

ISSN: 2040-2392