Fig. 11
From: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice
Effects of Myt1l haploinsufficiency on acoustic startle reactivity and pre-pulse inhibition of acoustic startle. A–C Acoustic startle reactivity is increased in male but not female Myt1l+/- mice. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor startle sound intensity (I), followed by unpaired t tests when appropriate. I: F4,208 = 84.359; p < .001; IxGxS: F4,208 = 3.648; p = .007, S: F1,52 = 4.662; p = .035; GxS: F1,52 = 4.574; p = .037; all other p > 0.050. D–F Pre-pulse inhibition of acoustic startle is unchanged in male and female Myt1l+/- mice. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor pre-pulse sound intensity (I), followed by unpaired t tests when appropriate. I: F3,156 = 95.448; p < .001; IxS: F3,156 = 9.664; p < .001; IxGxS: F3,156 = 3.071; p = .030; S: F1,52 = 8.443; p = .005; all other p > 0.050. D′–F′ Pre-pulse inhibition of acoustic startle is unchanged in male and female Myt1l+/- mice also after correcting for baseline differences in startle reactivity. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor pre-pulse sound intensity (I), followed by unpaired t tests when appropriate. I: F2,104 = 80.919; p < .001; IxS: F2,104 = 5.880; p = .004; S: F1,52 = 6.643; p = .013; all other p > 0.050. All data are means ± SEM, combined across males and females if not otherwise indicated; *p < 0.05; **p < 0.01; ***p < 0.001