Fig. 7
From: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice
Effects of Myt1l haploinsufficiency on locomotor activity and habituation learning in the activity box. A–A′ Locomotor activity is increased in Myt1l+/- mice. Repeated-measures ANOVA with the between-subject factors genotype (G) and sex (S) and the within-subject factor time (T). T: F29,1508 = 3.848; p < .001; TxG: F29,1508 = 1.819; p = .005; TxS: F29,1508 = 1.634; p = .018; G: F1,52 = 8.682; p = .005; S: F1,52 = 11.948; p = .001; all other p > 0.050. B–B′ Rearing behavior is increased in Myt1l+/- mice. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor time (T). T: F29,1508 = 2.760; p < .001; G: F1,52 = 17.237; p < .001; GxS: F1,52 = 5.395; p = .024; all other p > 0.050. C–C′ Locomotor activity remains high in Myt1l+/- mice during the second exposure to the activity box. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor time (T). TxS: F29,1508 = 1.853; p = .004; G: F1,52 = 15.266; p < .001; S: F1,52 = 22.731; p < .001; GxS: F1,52 = 9.918; p = .003; all other p > 0.050. D–D′ Rearing behavior remains high in Myt1l+/- mice during the second exposure to the activity box. Repeated-measures ANOVAs with the between-subject factors genotype (G) and sex (S) and the within-subject factor time (T). T: F29,1508 = 4.570; p < .001; TxS: F29,1508 = 2.086; p = .001; G: F1,52 = 11.525; p < .001; all other p > 0.050. All data are means ± SEM, combined across males and females; *p < 0.05; **p < 0.01; ***p < 0.001; #p < 0.05 versus day 1