Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content
Fig. 2 | Molecular Autism

Fig. 2

From: Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice

Fig. 2

Early life or post-adolescent sleep disruption. A Experimental design. Cohorts of mice undergo 7 days of sleep disruption either from P14–P21: early life sleep disruption (ELSD), or from P56–P63: post-adolescent sleep disruption (PASD). Control cohorts are left undisturbed. Control, ELSD, and PASD cohorts include male and female WT and Shank3WT/ΔC heterozygous littermates. Upon reaching adulthood (P70), control, ELSD, and PASD cohorts undergo a panel of behavioral testing lasting 6–7 weeks. B Control and ELSD pups were weighed daily from P14–P21. No differences were seen between groups (2-way ANOVA). N = 37 control pups; 39 ELSD pups. C Separate cohorts of control and ELSD treatment were killed at P21, and serum corticosterone (cort.) was measured using ELISA. No differences were seen between groups (unpaired t test). N  = 17 control, 33 ELSD. Error bars indicate ± SEM. See also Additional file 3

Back to article page

Molecular Autism

ISSN: 2040-2392