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Table 4 Primary analyses repeated using categorical measures of maternal circulating total 25(OH)D (nmol/L) in pregnancy

From: Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study

Outcome

Vitamin D group

Complete record analysis

Multiple imputation analysis

Effect estimate

95% CI

Effect estimate

95% CI

Autism diagnosis a

Unadjusted

    

Deficient

0.76

(0.18, 3.17)

0.93

(0.37, 2.33)

Insufficient

1.20

(0.71, 2.04)

0.94

(0.36, 2.43)

Fully adjusted

    

Deficient

0.91

(0.22, 3.83)

0.79

(0.31, 1.99)

Insufficient

1.28

(0.75, 2.19)

0.85

(0.33, 2.22)

Social communication trait a

Unadjusted

    

Deficient

1.18

(0.76, 1.82)

0.93

(0.66, 1.32)

Insufficient

1.11

(0.91, 1.35)

1.01

(0.71, 1.42)

Fully adjusted

    

Deficient

1.14

(0.73, 1.78)

1.00

(0.70, 1.41)

Insufficient

1.08

(0.88, 1.31)

1.02

(0.72, 1.45)

Speech coherence trait a

Unadjusted

    

Deficient

1.15

(0.71, 1.88)

0.95

(0.67, 1.34)

Insufficient

1.31

(1.06, 1.60)

1.07

(0.76, 1.51)

Fully adjusted

    

Deficient

1.17

(0.71, 1.92)

0.96

(0.68, 1.36)

Insufficient

1.31

(1.06, 1.61)

1.07

(0.75, 1.51)

Repetitive behaviours traita

Unadjusted

    

Deficient

1.32

(0.92, 1.91)

0.83

(0.64, 1.09)

Insufficient

1.18

(1.00, 1.39)

0.97

(0.74, 1.28)

Fully adjusted

    

Deficient

1.30

(0.90, 1.88)

0.86

(0.66, 1.13)

Insufficient

1.17

(0.99, 1.38)

0.97

(0.74, 1.28)

Sociability temperament traita

Unadjusted

    

Deficient

0.60

(0.32, 1.11)

1.14

(0.75, 1.72)

Insufficient

1.12

(0.91, 1.39)

1.23

(0.80, 1.87)

Fully adjusted

    

Deficient

0.61

(0.32, 1.14)

1.14

(0.75, 1.72)

Insufficient

1.15

(0.93, 1.43)

1.23

(0.80, 1.88)

Autism factor mean scoreb

Unadjusted

    

Deficient

0.03

(−0.10, 0.16)

−0.08

(−0.19, 0.03)

Insufficient

0.10

(0.04, 0.15)

0.00

(−0.12, 0.11)

Fully adjusted

    

Deficient

0.05

(−0.08, 0.17)

−0.09

(−0.19, 0.02)

Insufficient

0.09

(0.04, 0.15)

−0.02

(−0.13, 0.09)

  1. Deficient: < 25 nmol/L; insufficient: 25–50 nmol/L; sufficient: > 50 nmol/L
  2. All estimates relative to sufficient vitamin D
  3. Fully adjusted = adjusted for offspring sex, financial difficulties, maternal education, and maternal occupational class, parity, maternal age at birth, pre-pregnancy BMI and smoking status during pregnancy
  4. aEffect estimate = odds ratio
  5. bEffect estimate = mean difference