Sex-specific and sex-independent steroid-related biomarkers in early second trimester maternal serum associated with autism

Table 7 Association between sex hormone binding globulin and Body Mass Index (BMI) by autism status

Cohort	Crude models			Adjusted models^a			Sensitivity Analyses^b
Cohort	β	95% CI	P Value	β	95% CI	P Value	β	95% CI	P Value
Overall	− 10.35	− 16.90–− 3.80	0.002	− 12.02	− 18.38–− 5.66	< 0.001	− 12.02	− 18.41–− 5.62	< 0.001
Autism status
Present	− 2.92	− 8.33–2.48	0.284	− 4.29	− 10.01–1.42	0.138	− 4.23	− 9.99–1.53	0.147
Absent	− 22.46	− 34.52–− 10.41	< 0.001	− 24.22	− 36.11–− 12.33	< 0.001	− 24.46	− 36.82–− 12.10	< 0.001

^aAdjusted for Principal Component Factor 1 (PCF 1: gestational age, birthweight), Principal Component Factor 2 (PCF 2: maternal age, paternal age, maternal education duration, paternal education duration), gestational weight gain, newborn sex
^bAdjusted for PCF 1, PCF 2, gestational weight gain, newborn sex, and Principal Component Factor 3 (PCF 3: total testosterone, free testosterone, and estradiol levels)

ISSN: 2040-2392