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Fig. 4 | Molecular Autism

Fig. 4

From: Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism

Fig. 4

C-Fos is not induced in layer IV but increased in BLA of Foxp1-cKO mice by whisker stimulation. A–B c-Fos immunolabeling in the barrel cortex (A), hippocampus (A), and BLA (B) of WT and cKO mice 2 h following repeated whisker stimulation. White dot lines indicate the border between the cortex and hippocampus. Scale bars, 500 μm in (A), 200 μm in (B). C–E Quantification of c-Fos positive cells in cortical layers of WT and Foxp1-cKO mice. Circles (Blue: WT; Red: Foxp1-cKO) represent the average cell number for each animal (3 animals per genotype; 3 sections per animal). Ns, no significant difference; **p < 0.01. F–G Statistics of c-Fos positive cells in the hippocampus (F) and BLA (G). Circles represent the c-Fos+ cell density for each animal (3 animals per genotype; 3 sections per animal). Ns, no significant difference; ***p < 0.001

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Molecular Autism

ISSN: 2040-2392