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Fig. 8 | Molecular Autism

Fig. 8

From: Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism

Fig. 8

Foxp1-cKO mice display fewer thalamocortical synapses. A Representative images of spines on dendritic branches of the spiny stellate neurons from KO and WT mice. Scale bar, 2 μm. B Histogram of the mean spine counts on 20 μm long dendrites. Circles (Blue: WT; Red: Foxp1-cKO) represent the average density of all analyzed segments from each animal (12 segments per animal), n = 3 brains per genotype. **p < 0.01. C Brain coronal sections were immunostained for VGluT2 and PSD-95. Scale bar, 20 μm. D Statistics of puncta number of VGluT2+PSD-95+ excitatory thalamocortical synapses per 100 mm2 in layer IV of S1. Circles represent the average puncta number for each animal (3 animals per genotype; 3 sections per animal). *p < 0.05

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Molecular Autism

ISSN: 2040-2392