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Fig. 3 | Molecular Autism

Fig. 3

From: Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations

Fig. 3

TSC1−/− NPCs recapitulate translation observed in ASD BA19 samples. A Scatter plots from anota2seq analysis (left two panels) where transcripts whose translation was activated or suppressed in TSC1−/− versus TSC1+/+ NPCs (i.e., from Fig. 1B) are indicated in TSC1−/− versus TSC1+/+ NPCs and ASD versus control comparisons. Shown are also empirical cumulative distribution function (ECDF) plots assessing regulation of the same gene sets relative to the background (i.e., genes not in gene set) for polysome-associated and cytosolic mRNA log2 fold changes (ASD vs control BA19; two rightmost plots). Wilcoxon rank-sum test p values are indicated for the comparison of each gene set relative to the background. B Scatter plots and ECDF plots (similar to A) assessing regulation of transcripts whose translation were altered in ASD versus control BA19 in the comparison of TSC1−/− versus TSC1+/+ NPCs. C, D ECDF plots assessing genes related to synaptic activation and transcripts whose translation increased upon eIF4E overexpression. Signatures were evaluated in TSC1−/− versus TSC1+/+ NPCs (left two panels) and ASD versus control BA19 (right two panels). Fold changes were calculated using polysome-associated mRNA (C) or cytosolic mRNA (D). Wilcoxon rank-sum test p values are indicated for the comparison of each gene set relative to the background (i.e., genes not in gene sets)

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Molecular Autism

ISSN: 2040-2392