Fig. 1

Outline of study design and main analyses at the phenotypic and genotypic levels. Grey boxes outline the steps where questionnaire items were removed with the exclusion thresholds listed to the right. Boxes indicate an analysis with the arrows denoting analyses which are based on (i.e., factor structure) or used results (i.e., summary statistics) from a previous analysis. Analyses conducted at the phenotypic level with no sample size listed were conducted in the full sample (N = 58,630). Half-samples for the EFA/CFA conducted in the phenotypic level were randomly selected halves of the full sample. Estimating rg refers to estimation of genetic correlations of the items/factors with neurodevelopmental conditions. 1 With the assumptions of an OR of 1.2, MAF of 0.01, and alpha of 0.01 in a logistic model with additive genetic effects. 2 Only common factor models with 3+ items run. 3 Common factor GWAS only run on models with good fits and significant factor loadings