Fig. 2

Typical excitability of CA1 pyramidal cells. (A) Representative traces of whole cell recordings from WT (black, upper) and Cdkl5^−/y (green, lower) CA1 pyramidal cells in response to subsequent 25 pA steps. Traces shown from − 100 pA to rheobase-1 and for the maximum firing frequency (I = 400 pA). (B, B’) Input resistance. (C, C’) rheobase current. (D, D’) Action potential discharge in response to 500 ms long 25 pA current steps up to 400 pA (Two-way ANOVA genotype effect F_16,208=0.12, p = 0.66). Data shown as mean ± SEM (WT – n = 26 cells/8 rats, Cdkl5^−/y – n = 24 cells/7 rats, data points represent single cells (B, C, D) or animal averages (B’, C’, D’)