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Fig. 7 | Molecular Autism

Fig. 7

From: Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder

Fig. 7

Reduced mEPSC frequency and typical PPR in CA1 pyramidal cells from Cdkl5-/y rats. (A) Representative traces of mEPSC recordings from WT (left, black) and Cdkl5−/y (right, green) rats. (B–B’) mEPSC frequency. (C-C’) mEPSC amplitude: WT n = 24 cells / 9 rats, Cdkl5−/yn = 20 cells / 8 rats. (D) Cumulative distribution of inter-event interval. (E) Cumulative distribution of mEPSC amplitude. (F) Representative traces of EPSCs evoked by PP stimulation of Schafer collateral inputs to CA1 pyramidal cells from WT (upper, black) and Cdkl5−/y rats (lower, green) at an interstimulus interval of 50 ms. (G) PPR of evoked (WT n = 18 cells / 7 rats, Cdkl5−/yn = 9 cells / 5 rats) at paired-pulse intervals of 20, 50 and 100 ms. Data in bar charts shown as mean ± SEM (data points represent individual cells (B, C, G) or corresponding animal averages (B’, C’, G’)

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Molecular Autism

ISSN: 2040-2392