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Fig. 8 | Molecular Autism

Fig. 8

From: Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder

Fig. 8

CA1 pyramidal cell morphology and spine density across multiple dendritic compartments. (A) Example reconstruction of CA1 pyramidal cells from WT and Cdkl5−/y rats filled with biocytin during whole cell patch clamp recordings. (B) Sholl analysis of the dendritic arborisation (Two way ANOVA: Interaction: F 76,912 = 2.094, p < 0.001, genotype effect p = 0.38). (C) Total dendritic length, (D) total length of basal dendrites, (E) total length of apical dendrites. Data shown as mean ± SEM (WT - n = 14 cells/7 rats, Cdkl5−/y - n = 14 cells/7 rats, data points represent animal averages, all p values > 0.05, Two tailed t-test))

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Molecular Autism

ISSN: 2040-2392