Fig. 9

Spine density across dendritic compartments of CA1 pyramidal cells. (A) Representative segments of basal and apical (oblique and tuft) dendrites from CA1 pyramidal cells filled during whole-cell patch-clamp recordings. (B) Spine density in basal dendrites (WT: n = 12 cells/6 rats, Cdkl5^−/y: n = 12 cells / 7 rats). (C) Spine density in apical oblique dendrites (WT: n = 9 cells / 6 rats, Cdkl5^−/y: n = 12 cells / 6 rats). (D) Spine density in apical tuft dendrites (WT: n = 7 cells/4 rats, Cdkl5^−/y: n = 11 cells / 7 rats). Data shown as mean ± SEM, data points represent cell (B, C, D) or animal averages (B’, C’, D’). *p < 0.05, ns p > 0.05 LMM