Fig. 1

Schematic summary of the study. We investigated the association between ASD PRS and forty-four brain magnetic resonance imaging (MRI) phenotypes among ~ 31,000 participants in the UK Biobank for whom quality-controlled data were available (Details in Supplementary Fig. 1). Primary analyses included sixteen MRI phenotype - total volumes of the brain, CSF, GM, WM, GM of whole cerebellum, brainstem and ten regions of the cerebellum (I_IV, V, VI, VIIb, VIIIa, VIIIb, IX, X, CrusI and CrusII). Secondary analyses included twenty-eight MRI phenotypes - sub-regional volumes of the cerebellum including the GM of the vermis and left and right lobules of each cerebellar region. L, left hemisphere; R, right hemisphere