Fig. 2
Associations between polygenic risk scores for ASD and the primary MRI phenotypes, Total Volumes. Bar charts of variance explained by ASD PRS (R2, y-axis) constructed at each of seven probability thresholds (0.001 ≥ PSNP ≤1, x-axis) for each of the sixteen total volumes: total volumes of the Brain, CSF, GM, WM, grey matter of the whole Cerebellum, Brainstem and ten regions of cerebellum (I-IV, V, VI, VIIb, VIIIa, VIIIb, IX, X, CrusI and CrusII). Blue bars indicate negative associations and red bars positive associations; asterisks indicate P values for association after FDR correction: *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. Polygenic risk scores for ASD were significantly negatively associated with the total volumes of the Brain, WM, Brainstem, and Cerebellar regions I-IV, IX, and X; and significantly positively associated with the CSF volume