Fig. 4
Associations between polygenic risk scores for ASD and the secondary MRI phenotypes, Sub-regional Volumes. Bar charts of variance explained by ASD PRS (R2, y-axis) constructed at each of seven probability thresholds (0.001 ≥ PSNP ≤1, x-axis), for each of the twenty-eight cerebellar regional volumes: grey matter of the Left and Right lobules of each cerebellar region (I-IV, V, VI, VIIb, VIIIa, VIIIb, IX, X, CrusI and CrusII) and eight Vermis areas (VI, VIIb, VIIIa, VIIIb, IX, X, CrusI and CrusII). Blue bars indicate negative associations and red bars positive associations; asterisks indicate P values for association after FDR correction: *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. Polygenic risk scores for ASD were significantly negatively associated with the volumes of the cerebellar regions I-IV (left), VIIIb (vermis) and X (vermis)