From: Developmental trajectories in infants and pre-school children with Neurofibromatosis 1
 | 24 months | 36 months | ||||||
---|---|---|---|---|---|---|---|---|
 | TD group | NF1 Group | TD group | NF1 Group | ||||
 | n | Mean [SD] | n | Mean [SD] | n | Mean [SD] | n | Mean[SD] |
Autism Diagnostic Interview—Revised (ADI-R) Diagnostic Algorithm | ||||||||
Qualitative Abnormalities in Reciprocal Social Interaction (A) | Â | N/A | Â | N/A | 18 | 0.94 [1.00] | 30 | 5.23 [4.79] |
Qualitative Abnormalities in Communication (B) | Â | Â | Â | Â | 18 | 0.67 [0.97] | 30 | 5.03 [4.42] |
Restricted, Repetitive and Stereotyped Patterns of Behaviour (C) | Â | Â | Â | Â | 18 | 0.39 [0.61] | 30 | 2.13 [2.60] |
Abnormality of Development Evident at or Before 36 Months (D) | Â | Â | Â | Â | 18 | 0.06 [0.24] | 30 | 1.83 [1.34] |
Meeting threshold for autism on ADI-R | Â | Â | Â | Â | 18 | 0 [0%)] | 30 | 5 [17%] |
Not meeting threshold for autism on ADI-R | Â | Â | Â | Â | 18 | 18 [100%] | 30 | 25 [83%] |
Autism Diagnostic Observation Schedule-2 (ADOS-2) | ||||||||
Module (n) (Toddler/Module 1/Module 2) | 24 | 24/0/0 | 24 | 21/3/0 | 20 | 0/0/20 | 17 | 0/16/1 |
Total scores | 24 | 3.67 [1.95] | 24 | 8.08 [6.64] | 20 | 4.35 [3.42] | 17 | 4.47 [3.86] |
Social Affect scores | 24 | 3.13 [1.80] | 24 | 6.83 [5.75] | 20 | 3.60 [2.84] | 17 | 3.65 [3.02] |
Restrictive and Repetitive Behaviour scores | 24 | 0.54 [0.72] | 24 | 1.25 [1.29] | 20 | 0.80 [0.95] | 17 | 0.82 [1.24] |
Number reaching threshold for Autism Spectrum Disorder or Autism on ADOS-2 | 24 | 0 [0%] | 24 | 11 [46%] | 20 | 5 [25%] | 17 | 4 [24%] |
Brief Observation of Symptoms of Autism (BOSA-MV) | ||||||||
Module (Toddler/Module 1) | 0 | 0/0 | 3 | 2/1 | 0 | 0/0 | 12 | 0/12 |
Total scores | Â | Â | 3 | 12.33 [4.93] | Â | Â | 12 | 8.17 [2.66] |
Algorithm scores | Â | Â | 3 | 6.00 [2.00] | Â | Â | 12 | 4.42 [1.44] |
Number reaching threshold for Autism Spectrum Disorder on the BOSA | Â | Â | 3 | 2 [67%] | Â | Â | 12 | 5 [42%] |
ADOS/BOSA combined | ||||||||
Number of participants reaching threshold for Autism | 24 | 0 [0%] | 27 | 13 [48%] | 20 | 5 [25%] | 29 | 9 [31%] |
Number of participants not reaching threshold for Autism | 24 | 24 [100%] | 27 | 14 [52%] | 20 | 15 [75%] | 29 | 20 [69%] |
Number of participants reaching threshold for Autism on both ADI-R and ADOS/BOSA | Â | N/A | Â | N/A | 18 | 0 [0%] | 29 | 4 [14%] |
Child Behavior Checklist ADHD subscale | ||||||||
T score | 22 | 51.86 [2.49] | 27 | 55.56 [7.84] | 21 | 51.10 [1.45] | 28 | 57.14 [6.88] |