Skip to main content

Table 3 Descriptive statistics for ADI-R, ADOS, BOSA and CBCL

From: Developmental trajectories in infants and pre-school children with Neurofibromatosis 1

 

24 months

36 months

 

TD group

NF1 Group

TD group

NF1 Group

 

n

Mean [SD]

n

Mean [SD]

n

Mean [SD]

n

Mean[SD]

Autism Diagnostic Interview—Revised (ADI-R) Diagnostic Algorithm

Qualitative Abnormalities in Reciprocal Social Interaction (A)

 

N/A

 

N/A

18

0.94 [1.00]

30

5.23 [4.79]

Qualitative Abnormalities in Communication (B)

    

18

0.67 [0.97]

30

5.03 [4.42]

Restricted, Repetitive and Stereotyped Patterns of Behaviour (C)

    

18

0.39 [0.61]

30

2.13 [2.60]

Abnormality of Development Evident at or Before 36 Months (D)

    

18

0.06 [0.24]

30

1.83 [1.34]

Meeting threshold for autism on ADI-R

    

18

0 [0%)]

30

5 [17%]

Not meeting threshold for autism on ADI-R

    

18

18 [100%]

30

25 [83%]

Autism Diagnostic Observation Schedule-2 (ADOS-2)

Module (n) (Toddler/Module 1/Module 2)

24

24/0/0

24

21/3/0

20

0/0/20

17

0/16/1

Total scores

24

3.67 [1.95]

24

8.08 [6.64]

20

4.35 [3.42]

17

4.47 [3.86]

Social Affect scores

24

3.13 [1.80]

24

6.83 [5.75]

20

3.60 [2.84]

17

3.65 [3.02]

Restrictive and Repetitive Behaviour scores

24

0.54 [0.72]

24

1.25 [1.29]

20

0.80 [0.95]

17

0.82 [1.24]

Number reaching threshold for Autism Spectrum Disorder or Autism on ADOS-2

24

0 [0%]

24

11 [46%]

20

5 [25%]

17

4 [24%]

Brief Observation of Symptoms of Autism (BOSA-MV)

Module (Toddler/Module 1)

0

0/0

3

2/1

0

0/0

12

0/12

Total scores

  

3

12.33 [4.93]

  

12

8.17 [2.66]

Algorithm scores

  

3

6.00 [2.00]

  

12

4.42 [1.44]

Number reaching threshold for Autism Spectrum Disorder on the BOSA

  

3

2 [67%]

  

12

5 [42%]

ADOS/BOSA combined

Number of participants reaching threshold for Autism

24

0 [0%]

27

13 [48%]

20

5 [25%]

29

9 [31%]

Number of participants not reaching threshold for Autism

24

24 [100%]

27

14 [52%]

20

15 [75%]

29

20 [69%]

Number of participants reaching threshold for Autism on both ADI-R and ADOS/BOSA

 

N/A

 

N/A

18

0 [0%]

29

4 [14%]

Child Behavior Checklist ADHD subscale

T score

22

51.86 [2.49]

27

55.56 [7.84]

21

51.10 [1.45]

28

57.14 [6.88]