Behavioral decline in Shank3Δex4–22 mice during early adulthood parallels cerebellar granule cell glutamatergic synaptic changes

Table 1 Comparison of studies demonstrating behavioral changes in Shank3 mutant mouse models with age

Publication		Multi-Time Point Comparison Studies				Current Study	Originating Study
Publication		Ferhat et al., 2023	Bauer et al., 2023	Thabault et al., 2023	Contestabile et al., 2023	Kshetri et al.,	Drapeau et al., 2018
Shank3 Deletion		Δ11	Δ11	Δ21	Δ4–22	Δ4–22	Δ4–22
Isoforms Deleted		a, b,c	a, b,c	a, c,d, e,f	a, b,c, d,e, f	a, b,c, d,e, f	a, b,c, d,e, f
Testing Light Cycle		Light	N/A	N/A	Light	Dark	Light
Ages Compared (weeks)		12, 32, 52	4–9, 13–18	10, 20,40	2–8	5–7, 12–20	3, 12–35
Separate Age Cohorts		Y/N	N	Y	N/A	Y	N
Sexes		M/F	M/F	M/F	M/F	M/F	M/F
Motor Function	Rotarod		↓		↓	↓	↓
	Beam Balance					↓	↓
	Gait					−	−
	Speed					−	−
	Strength		↓				↓
Social	3 Chamber/Free Social Preference	−	−		↓	↓	−
	3 Chamber Social Novelty					−	−
	Sociosexual	↑					↓
	Ultrasonic Vocalizations	−	−				−
Exploratory	Locomotion	↓	↓		−	↓	↓
Exploratory	Marble Burying		↓			↓	↓
Anxiety-like	Open Field Center Time		↓		↓	↓	↓
Anxiety-like	Zero/Plus Maze	−			↓	↓	↓
Repetitive/ Stereotyped	Grooming	↑	↑	↑		↑	↑
	Rearing			↑
	Nestlet Shredding		↑				↓
Memory	Y-Maze	−				−	−
Memory	Barnes/Star Maze	−	−				↓

Abbreviations Y, Yes; N, No; N/A, Not available; M, Male; F, Female; ↑, increase; ↓, decrease; –, no change in tested behaviors due to reduced Shank3 expression

ISSN: 2040-2392