Table 2 Somatosensory reflexes
Somatosensory Reflexes | Nesting | Genotype | P2 | P4 | P6 | P8 | P10 | P12 | P14 |
|---|---|---|---|---|---|---|---|---|---|
Grasping Reflex (n) | SN | WT | 2.19 ± 0.31 | 2.13 ± 0.24 | 2.38 ± 0.22 | 2.56 ± 0.16 | 2.94 ± 0.06 | 3.00 ± 0.00 | 3.00 ± 0.00 |
###, **, §§§, €€ |  | HET | 2.67 ± 0.18 | 2.28 ± 0.16 | 2.06 ± 0.25 | 2.67 ± 0.16 | 2.94 ± 0.06 | 3.00 ± 0.00 | 3.00 ± 0.00 |
|  |  | KO | 2.74 ± 0.17 | 2.89 ± 0.11 | 2.68 ± 0.15 | 2.89 ± 0.07 | 3.00 ± 0.00 | 2.95 ± 0.05 | 2.95 ± 0.05 |
|  | CN | WT | 2.75 ± 0.18 | 1.92 ± 0.34 | 2.50 ± 0.19 | 2.75 ± 0.13 | 2.92 ± 0.08 | 3.00 ± 0.00 | 3.00 ± 0.00 |
|  |  | HET | 2.42 ± 0.23 | 2.33 ± 0.28 | 2.33 ± 0.22 | 2.67 ± 0.19 | 3.00 ± 0.00 | 3.00 ± 0.00 | 3.00 ± 0.00 |
|  |  | KO | 2.71 ± 0.19 | 2.94 ± 0.06 | 2.94 ± 0.06 | 3.00 ± 0.00 | 2.94 ± 0.06 | 3.00 ± 0.00 | 3.00 ± 0.00 |
Forelimb Placing (n) | SN | WT | 0.31 ± 0.15 | 1.06 ± 0.30 | 2.06 ± 0.19 | 2.44 ± 0.22 | 2.75 ± 0.11 | 2.88 ± 0.09 | 2.81 ± 0.10 |
###,***,%%,§§§,$$,@,€€ |  | HET | 0.61 ± 0.18 | 0.94 ± 0.25 | 2.28 ± 0.21 | 2.56 ± 0.18 | 2.94 ± 0.06 | 3.00 ± 0.00 | 2.94 ± 0.06 |
|  |  | KO | 0.05 ± 0.05 | 0.21 ± 0.10 | 0.79 ± 0.24 | 1.26 ± 0.18 | 1.84 ± 0.19 | 2.05 ± 0.25 | 1.74 ± 0.21 |
|  | CN | WT | 0.25 ± 0.13 | 1.92 ± 0.36 | 2.67 ± 0.14 | 2.67 ± 0.26 | 2.83 ± 0.17 | 3.00 ± 0.00 | 3.00 ± 0.00 |
|  |  | HET | 0.58 ± 0.23 | 2.08 ± 0.29 | 2.58 ± 0.19 | 3.00 ± 0.00 | 2.75 ± 0.18 | 3.00 ± 0.00 | 3.00 ± 0.00 |
|  |  | KO | 0.00 ± 0.00 | 0.06 ± 0.06 | 0.76 ± 0.25 | 0.59 ± 0.19 | 1.29 ± 0.31 | 1.94 ± 0.23 | 2.24 ± 0.18 |
Righting Reflex (s) | SN | WT | 24.34 ± 4.37 | 21.77 ± 6.36 | 3.61 ± 0.86 | 1.17 ± 0.11 | 2.22 ± 0.84 | 0.83 ± 0.08 | 0.74 ± 0.09 |
###,§,Ω |  | HET | 25.63 ± 4.52 | 10.97 ± 2.53 | 4.86 ± 3.25 | 2.21 ± 1.06 | 0.89 ± 0.07 | 0.86 ± 0.08 | 0.65 ± 0.06 |
|  |  | KO | 11.74 ± 3.18 | 4.87 ± 1.80 | 1.68 ± 0.25 | 1.40 ± 0.11 | 1.98 ± 0.44 | 1.78 ± 0.58 | 1.16 ± 0.16 |
|  | CN | WT | 19.31 ± 4.47 | 23.31 ± 7.32 | 2.02 ± 0.26 | 7.56 ± 4.93 | 4.59 ± 3.51 | 5.28 ± 4.62 | 0.68 ± 0.10 |
|  |  | HET | 17.18 ± 3.69 | 24.8 ± 6.28 | 1.56 ± 0.27 | 1.21 ± 0.22 | 3.15 ± 1.79 | 0.82 ± 0.08 | 0.57 ± 0.08 |
|  |  | KO | 21.34 ± 4.25 | 11.29 ± 4.47 | 1.66 ± 0.15 | 5.20 ± 3.43 | 5.03 ± 3.44 | 1.42 ± 0.29 | 0.93 ± 0.17 |
Level Screen (n) | SN | WT | 0.31 ± 0.12 | 1.31 ± 0.15 | 2.13 ± 0.13 | 2.25 ± 0.14 | 2.75 ± 0.11 | 3.00 ± 0.00 | 3.00 ± 0.00 |
###,§§§,$ |  | HET | 0.28 ± 0.14 | 1.28 ± 0.16 | 1.83 ± 0.15 | 2.44 ± 0.15 | 2.67 ± 0.11 | 2.94 ± 0.06 | 3.00 ± 0.00 |
|  |  | KO | 0.42 ± 0.12 | 0.74 ± 0.20 | 1.89 ± 0.15 | 2.63 ± 0.11 | 2.79 ± 0.10 | 3.00 ± 0.00 | 3.00 ± 0.00 |
|  | CN | WT | 0.42 ± 0.15 | 1.17 ± 0.17 | 1.83 ± 0.11 | 2.00 ± 0.12 | 2.75 ± 0.13 | 2.92 ± 0.08 | 3.00 ± 0.00 |
|  |  | HET | 0.58 ± 0.15 | 1.25 ± 0.13 | 1.67 ± 0.14 | 2.42 ± 0.15 | 2.42 ± 0.15 | 2.92 ± 0.08 | 3.00 ± 0.00 |
|  |  | KO | 0.53 ± 0.15 | 0.82 ± 0.15 | 1.41 ± 0.19 | 2.41 ± 0.12 | 2.65 ± 0.12 | 3.00 ± 0.00 | 3.00 ± 0.00 |
Negative Geotaxis (s) | SN | WT | 60.00 ± 0.00 | 60.00 ± 0.00 | 60.00 ± 0.00 | 49.94 ± 5.41 | 12.4 ± 3.82 | 7.79 ± 0.80 | 9.43 ± 0.93 |
###,§§§ |  | HET | 60.00 ± 0.00 | 60.00 ± 0.00 | 60.00 ± 0.00 | 28.62 ± 6.11 | 16.2 ± 4.78 | 7.69 ± 0.85 | 12.26 ± 1.88 |
|  |  | KO | 57.15 ± 2.85 | 60.00 ± 0.00 | 50.84 ± 4.26 | 23.75 ± 4.14 | 17.09 ± 1.89 | 24.73 ± 3.90 | 41.33 ± 4.34 |
|  | CN | WT | 60.00 ± 0.00 | 60.00 ± 0.00 | 60.00 ± 0.00 | 44.96 ± 6.51 | 14.61 ± 4.70 | 7.16 ± 1.55 | 12.89 ± 3.12 |
|  |  | HET | 60.00 ± 0.00 | 60.00 ± 0.00 | 60.00 ± 0.00 | 43.56 ± 7.13 | 12.18 ± 4.63 | 8.84 ± 1.72 | 12.89 ± 2.94 |
|  |  | KO | 60.00 ± 0.00 | 60.00 ± 0.00 | 51.18 ± 4.00 | 34.5 ± 5.29 | 19.47 ± 3.26 | 19.06 ± 2.56 | 26.12 ± 4.91 |
Vertical Screen (s) | SN | WT | 1.03 ± 0.40 | 1.74 ± 0.32 | 8.79 ± 1.97 | 14.41 ± 2.77 | 18.51 ± 4.07 | 35.58 ± 5.59 | 49.23 ± 4.99 |
###,** |  | HET | 0.79 ± 0.25 | 2.59 ± 0.40 | 12.71 ± 3.43 | 14.39 ± 3.13 | 20.38 ± 3.74 | 30.54 ± 4.46 | 51.47 ± 4.44 |
|  |  | KO | 1.94 ± 0.55 | 6.32 ± 1.66 | 15.07 ± 3.59 | 12.58 ± 2.46 | 27.23 ± 5.80 | 38.21 ± 5.13 | 58.07 ± 1.72 |
|  | CN | WT | 0.86 ± 0.37 | 2.63 ± 0.65 | 11.15 ± 1.92 | 11.82 ± 2.14 | 24.04 ± 5.92 | 25.1 ± 6.35 | 60.00 ± 0.00 |
|  |  | HET | 0.00 ± 0.00 | 5.73 ± 2.35 | 9.88 ± 1.89 | 21.97 ± 4.12 | 11.70 ± 2.56 | 23.9 ± 5.48 | 56.51 ± 3.49 |
|  |  | KO | 0.32 ± 0.15 | 4.15 ± 1.24 | 11.06 ± 2.73 | 24.56 ± 5.47 | 30.94 ± 5.79 | 45.71 ± 5.03 | 60.00 ± 0.00 |
Cliff Avoidance (s) | SN | WT | 25.61 ± 2.39 | 30.00 ± 0.00 | 28.22 ± 1.66 | 15.88 ± 2.78 | 9.65 ± 2.10 | 11.18 ± 2.23 | 7.92 ± 2.35 |
###,§ |  | HET | 27.47 ± 1.75 | 28.88 ± 1.12 | 27.09 ± 1.62 | 20.3 ± 2.56 | 13.06 ± 2.15 | 9.00 ± 1.73 | 10.05 ± 2.63 |
|  |  | KO | 28.49 ± 1.51 | 21.63 ± 2.91 | 22.36 ± 2.72 | 20.59 ± 2.64 | 11.24 ± 2.55 | 16.22 ± 3.81 | 12.11 ± 2.66 |
|  | CN | WT | 21.43 ± 3.66 | 30.00 ± 0.00 | 27.82 ± 2.18 | 17.29 ± 3.37 | 10.59 ± 2.34 | 11.52 ± 1.48 | 8.25 ± 2.81 |
|  |  | HET | 27.62 ± 2.36 | 30.00 ± 0.00 | 28.09 ± 1.69 | 25.13 ± 2.16 | 13.43 ± 3.06 | 8.91 ± 1.92 | 7.10 ± 1.94 |
|  |  | KO | 23.45 ± 2.61 | 28.84 ± 1.16 | 25.33 ± 2.52 | 20.16 ± 3.01 | 15.36 ± 2.92 | 12.96 ± 3.04 | 7.20 ± 1.78 |
Bar Holding (s) | SN | WT | 2.87 ± 0.45 | 12.91 ± 4.67 | 35.48 ± 4.61 | 32.62 ± 4.55 | 14.68 ± 2.57 | 11.64 ± 1.59 | 14.75 ± 3.07 |
###,**,§ |  | HET | 2.86 ± 0.32 | 11.99 ± 2.78 | 32.15 ± 4.97 | 41.73 ± 4.62 | 19.73 ± 2.97 | 10.54 ± 0.87 | 15.62 ± 2.46 |
|  |  | KO | 3.31 ± 0.72 | 11.58 ± 2.95 | 25.81 ± 5.61 | 19.45 ± 2.77 | 8.94 ± 1.26 | 7.14 ± 1.45 | 7.09 ± 1.36 |
|  | CN | WT | 1.58 ± 0.32 | 5.09 ± 1.02 | 37.67 ± 5.88 | 29.26 ± 5.00 | 16.01 ± 3.18 | 10.67 ± 1.51 | 10.45 ± 1.63 |
|  |  | HET | 1.88 ± 0.26 | 8.10 ± 2.06 | 28.26 ± 5.73 | 29.17 ± 3.89 | 14.29 ± 1.99 | 9.01 ± 1.16 | 13.72 ± 2.88 |
|  |  | KO | 5.73 ± 3.41 | 12.88 ± 3.78 | 21.30 ± 4.99 | 22.66 ± 4.48 | 15.23 ± 2.73 | 5.07 ± 1.13 | 6.11 ± 1.14 |
Auditory Startle (s) | SN | WT | 0.00 ± 0.00 | 0.06 ± 0.06 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.63 ± 0.29 | 2.31 ± 0.30 |
###, + ,Ω |  | HET | 0.06 ± 0.06 | 0.11 ± 0.11 | 0.11 ± 0.11 | 0.06 ± 0.06 | 0.00 ± 0.00 | 0.28 ± 0.19 | 2.17 ± 0.25 |
|  |  | KO | 0.00 ± 0.00 | 0.05 ± 0.05 | 0.05 ± 0.05 | 0.05 ± 0.05 | 0.00 ± 0.00 | 0.26 ± 0.18 | 2.47 ± 0.22 |
|  | CN | WT | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 2.00 ± 0.35 |
|  |  | HET | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 2.17 ± 0.34 |
|  |  | KO | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.06 ± 0.06 | 2.18 ± 0.32 |