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Fig. 2 | Molecular Autism

Fig. 2

From: Evolutionary constrained genes associated with autism spectrum disorder across 2,054 nonhuman primate genomes

Fig. 2

Gene Set Enrichment Analysis (GSEA) using ASD SFARI gene set (A) and DisGeNET ASD gene set (B). The x-axis denotes all genes ranked by the RVIS. The black vertical line indicates the ASD set genes. The y-axis is the Enrichment Score (ES) which represents the degree (i.e., the maximum deviation from zero) to which a set of genes is over-represented at the top of the ranked list accordingly to the RVIS. C. The scatter plot of RVIS scores for ASD-associated genes. The blue plots are for the 2% extreme of the distribution i.e., most intolerant in which the annotated plot indicates the DisGeNET ASD set genes. The red plots indicate 98% of the rest of the genes

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Molecular Autism

ISSN: 2040-2392