Fig. 5

A. Density histogram of the Residual Variation Intolerance Scores (RVIS) for NDD (N = 101, blue) and non-NDD (N = 18,065, red) genes. The RVIS scores are normalised and hence the centre on a mean of 0. B. The box plots for any NDD genes (i.e., ASD, epilepsy, ID, schizophrenia) and non-NDD genes. The descriptions are the same as Fig. 2C and D. Box plots C. GSEA for the overlapped NDD genes