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Fig. 14 | Molecular Autism

Fig. 14

From: Comparative profiling of white matter development in the human and mouse brain reveals volumetric deficits and delayed myelination in Angelman syndrome

Fig. 14

Ultrastructure of the developing WT and AS corpus callosum. Representative electron micrographs of the corpus callosum body in (A1) a WT mouse and (B1) a AS littermate at P16. Representative electron micrographs showing examples of myelinated axons observed in (A2, A3, A4) a WT mouse and (B2, B3, B4) an AS littermate at P16. Representative electron micrographs of the corpus callosum body in (C1) a WT mouse and (D1) a AS littermate at P30. Representative electron micrographs showing examples of myelinated axons observed in (C2, C3, C4) a WT mouse and (D2, D3, D4) a AS littermate at P30. (E) and (F) Representative electron micrographs showing layers of compacted myelin around the axons shown in C4 and D4. Scale bars: (A1, B1, C1, D1) = 500 nm; (A2-4), (B2-4), (C2-4), (D2,4) = 125 nm, (E), (F) = 50 nm

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Molecular Autism

ISSN: 2040-2392