Fig. 10
From: Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice
Altered mRNA expression in Pdzd8tm1b mouse brain. Transcript levels of Atf4 and Hspa5 genes encoding ER stress markers, Fis1 gene encoding a mitochondrial fission protein, Mfn1, Mfn2 and Opa1 genes encoding mitochondrial fusion markers, and the Hprt and B2m reference genes. Gene mRNA expression is presented as fold change ± SEM, calculated via the 2-ΔΔCt method [30], relative to Hprt mRNA. Student’s t-test detected significant differences in male Pdzd8tm1b homozygous mice versus WT controls (n = 5♂/genotype). Normalizing to the B2m reference gene gave similar results. tm1b, Pdzd8tm1b homozygous; WT, wild-type. *p < 0.05, **p < 0.01 versus WT