Fig. 5
From: Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice
Impaired social recognition in Pdzd8tm1b mice. A–C Juvenile social interaction in Pdzd8tm1b mice (n = 8♀) and WT controls (n = 8♀). A Duration of social interaction (s). B Duration of anogenital sniffing (% of total interaction time). C Number of approaches toward juvenile mouse. D Social approach testing in Pdzd8tm1b mice (n = 12♀) and WT controls (n = 10♀). Sociability: time (% total) spent exploring an empty container versus a novel mouse (two-way ANOVA, genotype: F(1, 40) = 0.01, p = 0.903; chamber: F(1, 40) = 19.16, p = 0.0001; genotype × chamber interaction: F(1, 40) = 0.16, p = 0.693). Social recognition: time (% total) spent exploring stranger 1 (previously explored mouse) versus a second novel mouse (two-way ANOVA, genotype: F(1, 40) = 0.06, p = 0.809; chamber: F(1, 40) = 8.50, p = 0.006; genotype × chamber interaction: F(1, 40) = 4.65, p = 0.037). Empty, empty cylinder; S1, stranger 1; S2, stranger 2; tm1b, Pdzd8tm1b homozygous; WT, wild-type. ##p < 0.01 versus stranger 1 within WT group