Fig. 6
From: Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice
Social odour discrimination is altered in Pdzd8tm1b mice. A Cross-habituation assay for WT controls (n = 21; 13♂, 8♀) showing increased nose poke investigation times (s) when a new odor was presented after habituation (Friedman: F = 3.389, p = 0.000007). B Cross-habituation assay for Pdzd8tm1b mice (n = 16; 8♂, 8♀) showing investigation times lower than in WT controls but still significant (Friedman: F = 2.259, p = 0.0059). Asterisks indicate corrected post-hoc Wilcoxon tests. C A head-fixed Pdzd8tm1b mouse, the rectangle over the nose showing the region used for analysis. D Nasal movements measured from the rectangle in B for female and male urine, with stimuli delivered during shaded area. E, F Fourier transforms of the data in D, the gray traces showing the power for the pre-stimulus and the colored traces showing the power over the stimulus period. Shaded area shows frequency range of respiration. GPdzd8tm1b mice (n = 3; 2♂, 1♀) increased nasal movements in response to both female (corrected paired t-test: t = 14.507, p = 0.0094) and male urine (corrected paired t-test: t = 6.019, p = 0.027). dB, decibels; Hz, Hertz; IsoA, isoamyl acetate; Urine(f), urine from female mice; Urine(m), urine from male mice; WT, wild-type. *p < 0.05, **p < 0.01, ***p < 0.001