Fig. 7
From: Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice
Relative (% total brain volume) volumetric differences in the cerebellar nuclei, accessory olfactory bulb, and components of the primary olfactory cortex in Pdzd8tm1b mice (n = 32; 10♂, 22♀) and WT controls (n = 17; 7♂, 10♀) determined by high-resolution structural magnetic resonance imaging. A Cerebellar nuclei relative volume is decreased in Pdzd8tm1b mice by 8.56 ± 0.79% (unpaired t-test: t = 7.83, p < 0.0001). B Accessory olfactory bulb relative volume is increased in Pdzd8tm1b mice by 10.79 ± 1.38% (unpaired t-test: t = 6.18, p < 0.0001). C Anterior olfactory nucleus relative volume is increased in Pdzd8tm1b mice by 11.99 ± 0.92% (unpaired t-test: t = 11.03, p < 0.0001). D Piriform cortex relative volume is increased in Pdzd8tm1b mice by 10.58 ± 0.72% (unpaired t-test: t = 12.87, p < 0.0001). E Entorhinal cortex relative volume is increased in Pdzd8tm1b mice by 2.57 ± 0.66% (unpaired t-test: t = 2.94, p = 0.005). tm1b, Pdzd8tm1b homozygous; WT, wild-type. **p < 0.01, ****p < 0.0001 versus WT