Fig. 9
From: Autistic behavior is a common outcome of biallelic disruption of PDZD8 in humans and mice
Greater density of dendritic spines in the hippocampal CA1 and the granule cell layer of the OB in Pdzd8tm1b mice. A Density of dendritic spines in the hippocampal CA1 of Pdzd8tm1b mice (n = 69 dendrites from n = 4♂ mice) and WT controls (n = 87 dendrites from n = 4♂ mice) (two-sample t-test: t(154) = 3.221, p = 0.0016). B Representative images of dendritic segment of Golgi–Cox-stained neurons in hippocampal CA1 of Pdzd8tm1b mouse (right) and WT control (left). Scale bar: 4 μm. C The density of dendritic spines in the granule cell layer of the OB was higher (two-sample t-test with Welch’s correction: t(79.4) = 4.145, p = 0.000084) and less variable (Levene’s test, p = 0.017) in Pdzd8tm1b mice (n = 27 dendrites from n = 4♂ mice) compared with WT controls (n = 57 dendrites from n = 4♂ mice). D Representative images of dendritic segment of Golgi–Cox-stained neurons in the granule cell layer of the OB of WT control (left) and Pdzd8tm1b mouse (right). Scale bar: 4 μm. tm1b, Pdzd8tm1b homozygous; WT, wild-type. **p < 0.01, ***p < 0.001 versus WT