Table 2 Comparative summary of ASD/ADHD-relevant phenotypes of the Pdzd8^tm1b and Pdzd8^em1Kei mouse lines

Pdzd8 gene disruption

Replacement of exon 3 by lacZ cassette

Deletion of exon 1

[2, 5]

Effect on PDZD8 protein

p.(F333Nfs1*)

Protein null

Genetic background

C57BL/6NTac

C57BL/6J

[2, 5]

Zygosity

Homozygous

Homozygous

Sex

♂

♀

♂

♀

Repetitive jumping

>>

>>

–

–

[2]

Locomotor activity

 Open field

>

>

ns

–

[2, 27]

 In-cage ambulation

> (dark)

–

>

–

Figure 3A, B, [71]

 Wheel running

>> (dark)

–

–

–

Figure 3C, D

Elevated plus maze

[2, 71]

 Open arm entries

>

>

>>

–

 Open arm time

ns

ns

>>

–

Social interaction time

 with C57BL/6J juvenile ♀

–

ns

–

–

Figure 5A

 with same genotype adult ♂

–

–

ns

–

[71]

3-chamber social approach

Figure 5D, [71]

 Sociability

–

ns

ns

–

 Social novelty preference

–

<

ns

–

Social odor discrimination

<<

<<

–

–

Figure 6