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Fig. 3 | Molecular Autism

Fig. 3

From: Flexible nonlinear modeling reveals age-related differences in resting-state functional brain connectivity in autistic males from childhood to mid-adulthood

Fig. 3

Fully disrupted linear age-related pathways in ASD. Between-network connections displayed fully disrupted age-related pathways in ASD, demonstrated by entirely different model fits compared to TD. TD between-network SMN development increased in childhood and stabilized or decreased in young adulthood. Contrarily, ASD SMN connectivity was best modeled by an increasing linear model, displaying group-by-age interactions in ASD. Similarly, both the anterior VAN and MSP-CEN had disrupted connectivity-age-related pathways with the posterior DAN. A similar trend was seen in limbic-VAN connectivity. All results are FDR-corrected. Shaded areas denote regions of pairwise differences between groups. Acronyms: somatomotor network (SMN), dorsal attention network (DAN), medial temporal limbic (MT-limbic), medial superior parietal (MSP), ventral attention network (VAN)

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Molecular Autism

ISSN: 2040-2392